发明名称 |
GENETIC RECOMBINANT ECARIN AND PROCESS FOR PREPARING THE SAME |
摘要 |
A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as to produce and accumulate ecarin in culture supernatant or within said transformant and recovering the produced ecarin; and (2) purifying a solution containing the recovered ecarin to obtain purified ecarin. The present invention allows for production of recombinant ecarin on an industrial scale.
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申请公布号 |
US2008153132(A1) |
申请公布日期 |
2008.06.26 |
申请号 |
US20070950638 |
申请日期 |
2007.12.05 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO- THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
YONEMURA HIROSHI;IMAMURA TAKAYUKI;NAKATAKE HIROSHI;SOEJIMA KENJI;NOZAKI CHIKATERU |
分类号 |
C12P21/04;C07K16/00;C12N9/64;C12N15/12 |
主分类号 |
C12P21/04 |
代理机构 |
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代理人 |
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地址 |
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