PROCESS OF PRODUCING AMOROLFINE

摘要

The present invention refers to an improved process of producing Amorolfine base, which is a compound of formula (I) said process comprising the steps of : (i) contacting a compound of formula (II) with a Friedel-Crafts catalyst; and (ii) adding one equivalent of 2-halogeno-2- methylbutane, characterised in that the reaction mixture obtained in step (i) is cooled to a temperature between -40 to -60 °C prior to step (ii) and the Friedel-Craft catalyst is chosen among the group consisting of gallium chloride, antimony pentafluoride, molybdenum pentachloride, indium chloride, antimony pentachloride.