5- [4- (AZETIDIN-3-YL0XY) -PHENYL] -2-PHENYL-5H-THIAZ0L0 [5,4-C] PYRIDIN-4-0NE DERIVATIVES AND THEIR USE AS MCH RECEPTOR ANTAGONISTS

摘要

The present invention relates to a melanin concentrating hormone antagonist compound of formula I: wherein "-----" is absent or is optionally a bond; q is 1 or 2; R<SUP>1</SUP> is independently selected from hydrogen, -C<SUB>1</SUB>-C<SUB>2</SUB> alkyl, halo, hydroxy, -C<SUB>1</SUB>-C<SUB>2</SUB> haloalkyl, -C<SUB>1</SUB>-C<SUB>3</SUB> alkoxy, cyano, -O-C<SUB>3</SUB>-C<SUB>4</SUB> cycloalkyl, and -OC<SUB>1</SUB>-C<SUB>2</SUB> haloalkyl; R<SUP>2</SUP> is selected from the group consisting of hydrogen, -C<SUB>1</SUB>-C<SUB>3</SUB> alkyl, hydroxy, -C<SUB>1</SUB>-C<SUB>3</SUB> alkoxy, cyano, -C<SUB>1</SUB>-C<SUB>2</SUB> haloalkyl, -OC<SUB>1</SUB>-C<SUB>2</SUB> haloalkyl, and halo; R<SUP>3</SUP> is selected from the group consisting of hydrogen, -C<SUB>1</SUB>-C<SUB>4</SUB> alkyl, -C<SUB>2</SUB>-C<SUB>4</SUB> haloalkyl, -C<SUB>2</SUB>-C<SUB>4</SUB> alkylOH, -C<SUB>3</SUB>-C<SUB>6</SUB> cycloalkyl, -CH<SUB>2</SUB>C<SUB>3</SUB>-C<SUB>6</SUB> cyxloalkyl, -C<SUB>2</SUB>-C<SUB>4</SUB> alkyl-O-C<SUB>1</SUB>-C<SUB>4</SUB> alkyl, -C(O)C<SUB>1</SUB>-C<SUB>4</SUB> alkyl, -C(O)C<SUB>1</SUB>-C<SUB>4</SUB> haloalkyl, -CH<SUB>2</SUB>-thiazole, phenyl, benzyl, tetrahydrothiopyranyl, and tetrahydropyranyl, wherein the cycloalkyl, tetrahydrothiopyranyl, tetrahydropyranyl and thiazolyl group is optionally substituted with one or two groups independently selected from the group consisting of halo, hydroxy, C<SUB>1</SUB>-C<SUB>2</SUB> alkyl, and -C<SUB>1</SUB>-C<SUB>2</SUB> haloalkyl; or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture thereof,, useful in the treating, preventing or ameliorating of symptoms associated with obesity and related diseases.