AN ACTIVATION EPITOPE OF FCGAMMARII (CD32), BINDING MOLECULES THAT SPECIFICALLY BIND THE EPITOPE AND MEANS AND METHODS FOR THE DETECTIONOF EPITOPE, AND USES OF SAID EPITOPE OR SAID BINDING MOLECULES.

摘要

The present invention provides means and method for detecting an activati on epitope on FcyRII (CD32) on Fc.gamma. (CD32) expressing cells. The presen ce of epitope on Fc.gamma.RII (CD32) correlates with priming of the cell con taining Fc.gamma.RII (CD32) expressing said epitope. The invention further p rovides binding molecules specific for said activation epitope on Fc.gamma.R II (CD32), and uses thereof in the detection of activated cells. Further use s are the treatment of individuals suffering from inflammation or at risk of suffering thereof. Also provided, among others, are uses for detecting and/ or following an inflammation in an individual.