发明名称 |
CODON-OPTIMIZED GENES FOR THE PRODUCTION OF POLYUNSATURATED FATTY ACIDS IN OLEAGINOUS YEASTS |
摘要 |
The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to gamma-linolenic acid (GLA); alpha-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-gamma-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to ETA; eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA); and arachidonic acid (ARA) to EPA. Nucleic acid sequences encoding codon-optimized desaturases and elongases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the codon-optimized desaturase or elongases, and recombinant host microorganisms expressing increased levels of desaturase or elongase are described.
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申请公布号 |
US2008154027(A1) |
申请公布日期 |
2008.06.26 |
申请号 |
US20080018222 |
申请日期 |
2008.01.23 |
申请人 |
PICATAGGIO STEPHEN K;ZHU QUINN QUN |
发明人 |
PICATAGGIO STEPHEN K.;ZHU QUINN QUN |
分类号 |
C07H21/00;C07H21/04;C12N;C12N1/18;C12N9/02;C12N9/10;C12N15/74;C12P7/64;C12Q1/68 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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