TRANSCRIPTION FACTOR DECOY

摘要

Double-stranded oligonucleotides useful as decoy oligonucleotides having a high binding ability to a transcription factor and having a reduced cytotoxicity are disclosed. Each of the double-stranded oligonucleotides is formed by hybridization of a sense strand oligonucleotide of the following Formula A:

        5'-N(m)-G-Consensus Sequence-C-N(n)-3'     (Formula A)

(wherein N(m) is a flanking sequence at the 5'-end, and represents that "N"(s) in the number of m is(are) ligated; N(n) is a flanking sequence at the 3'-end, and represents that "N"(s) in the number of m is(are) ligated; all "N"(s) each independently represent(s) nucleotide A, G, T, C or U; m and n represent each independently an integer of 0 to 20; and Consensus Sequence represents a consensus sequence to which a transcription factor binds)
and an antisense strand oligonucleotide complementary to said sense strand oligonucleotide.