发明名称 |
METHODS AND MATERIALS FOR IDENTIFYING THE ORIGIN OF A CARCINOMA OF UNKNOWN PRIMARY ORIGIN |
摘要 |
<p>The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the algorithm or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.</p> |
申请公布号 |
EP1934615(A2) |
申请公布日期 |
2008.06.25 |
申请号 |
EP20060814892 |
申请日期 |
2006.09.19 |
申请人 |
VERIDEX, LLC |
发明人 |
WANG, YIXIN;MAZUMDER, ABHIJIT;TALANTOV, DMITRI;JATKOE, TIMOTHY;BADEN, JONATHAN |
分类号 |
G01N33/574;C12Q1/68;G01N33/48 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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