| 摘要 |
<p>The invention relates to a method and device for the objective measurement of the therapy compliance of patients who are undergoing prescribed medication therapy. The medication is provided in blister packages upon which a polymer-based electronic circuit is printed directly on the blister film (2) or foil (1), using so-called intelligent system-in-foil or system-on-foil technology. In a first embodiment of the invention, the printed polymer circuit comprises a number of conductive tracks (3), which run under each blister so that when a pill is expelled from the blister breaking the foil seal, the corresponding track is broken. These tracks are connected to a silicon or printed polymer integrated circuit (6) that records the event when a track is broken and stores this information, including the time of the event and the position of the blister and any other clinically relevant data. In a second embodiment of the invention, a polymer or electret microphone (11) is used to detect the sound that is generated when a pill is expelled from a blister, breaking the foil seal in the process. In this embodiment, the microphone is connected to a silicon or printed polymer integrated circuit (12) that records the event when the seal is broken and stores this information, including the time of the event and the position of the blister and any other clinically relevant data. The electronic circuit also contains RFID (Radio Frequency IDentification) technology to enable the information stored in the integrated circuit to be accessed using an RFID reader. Furthermore, the integrated circuit of both embodiments can be programmed using the RFID interface during the blister-filling phase with information about the filling medication, including unique codes to counteract counterfeiting, and logistical data. The circuit further comprises an antenna (10) and a power source (9), both of which can be printed during the same, or a separate, system-in-foil and/or system-on-foil process or mounted as discrete components. The intelligent system-in-foil or system-on-foil in accordance with the invention replaces the standard film or foil currently used in the existing standard blister packaging manufacturing process.</p> |
