发明名称 |
Composition for solid pharmaceutical preparation of solifenacin or salt thereof |
摘要 |
A solid pharmaceutical preparation of solifenacin or a salt thereof, the preparation being stable and inhibited from decomposing with time when supplied to clinical fields. In a pharmaceutical preparation containing solifenacin or a salt thereof, the compound in an amorphous form was revealed to be causative of cardinal-drug decomposition with time. The composition for a solid pharmaceutical preparation of solifenacin or a salt thereof contains solifenacin or its salt each in a crystalline form, and the content of the compound in an amorphous form in the composition is within the range which exerts no influence on product stability. Also provided are: a process for producing the composition; and a medicinal composition for solid pharmaceutical preparations which contains solifenacin and an amorphization inhibitor. |
申请公布号 |
ZA200608614(B) |
申请公布日期 |
2008.06.25 |
申请号 |
ZA20060008614 |
申请日期 |
2005.03.24 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
SUGIHARA, AKIO;YASUJI, TAKEHIKO;MASAKI, KATSUHIRO;MURAYAMA, DAISUKE |
分类号 |
A61K;A61P;C07D |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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