发明名称 |
SASPase-Knockout Mouse |
摘要 |
<p>Knockout animals in which a gene encoding a SASPase has been deleted (hereinafter, referred to as SASPase KO animals) are provided. The SASPase KO animals deficient in expression of functional SASPase were produced by deleting a gene encoding a stratified epithelium-specific protease, SASPase, through targeted disruption. The SASPase KO animals showed a significant increase in wrinkles on the sides of the body and so on. The SASPase KO animals find utility as animal models of wrinkles.</p> |
申请公布号 |
EP1935243(A1) |
申请公布日期 |
2008.06.25 |
申请号 |
EP20060811174 |
申请日期 |
2006.10.04 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
MATSUI, TAKESHI;KISUMI, FUMIE |
分类号 |
A01K67/027;C12N9/64;C12N15/09;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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