发明名称 PROCESS FOR PRODUCING OPTICALLY ACTIVE FLUOROBENZYL ALCOHOL
摘要 A fluorine-containing benzaldehyde is reacted with an alkyl Grignard reagent to convert it to a magnesium alkoxide of racemic, fluorine-containing, benzyl alcohol, and subsequently the magnesium alkoxide is reacted with phthalic anhydride to obtain a phthalate half ester of racemic, fluorine-containing, benzyl alcohol, and the half ester is optically resolved by optically active 1-phenylethylamine, and then the ester group is hydrolyzed, thereby producing an optically active, fluorine-containing, benzyl alcohol.
申请公布号 EP1935866(A1) 申请公布日期 2008.06.25
申请号 EP20060811202 申请日期 2006.10.04
申请人 CENTRAL GLASS COMPANY, LIMITED 发明人 ISHII, AKIHIRO;UEDA, KOJI;YASUMOTO, MANABU
分类号 C07C29/09;C07B57/00;C07C33/46;C07C67/08;C07C69/80 主分类号 C07C29/09
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