发明名称 |
Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy |
摘要 |
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional molecule is administered to the host. The bifunctional molecule binds to the presenter protein to produce a binary complex that exhibits at least one of improved affinity, specificity or selectivity as compared to the corresponding free drug. The subject methods and compositions find use in a variety of therapeutic applications.
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申请公布号 |
US7390784(B2) |
申请公布日期 |
2008.06.24 |
申请号 |
US20040011499 |
申请日期 |
2004.12.13 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
BRIESEWITZ ROGER;CRABTREE GERALD R.;WANDLESS THOMAS;RAY GREGORY THOMAS;VOGEL KURT W. |
分类号 |
A61K38/00;A61K38/17;A61K38/52;A61K47/48;C07K1/00;C07K5/10;C07K7/06;C07K17/02;C12N9/90;C12N11/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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