SCREENING METHODS FOR CANDIDATE MATERIALS HAVING WHITENING ACTIVITY

摘要

A method for screening a material with whitening activity is provided to use an NQ01(NADPH quinone reductase 1) involving with an in vivo pigmentation and having an amino acid sequence of SEQ ID : NO. 1, 2 or 3 or an isoform thereof as a target for screening the material with whitening activity. A method for screening a material with whitening activity comprises the steps of: (a) treating a protein having an amino acid sequence selected from the group consisting of amino acid sequences of SEQ ID : NOs. 1 to 3 with a candidate material; and (b) selecting a material decreasing the activity of the protein by measuring activity change of the protein obtained form the step(a) through a benzo(a)pyrene quinones-reduction analysis or Western blotting.