Morpholinylholdige benzimidazoler som inhibitorer af respiratorisk syncytialvirus-replikation

摘要

The present invention concerns morpholinyl containing benzimidazoles having inhibitory activity on the replication of the respiratory syncytial virus and having the formula (I), a prodrug, N-oxide, addition salt, quaternary amine, metal complex or stereochemically isomeric form thereof wherein G is a direct bond or optionally substituted C1-10alkanediyl; R is Ar<1> or a monocyclic or bicyclic heterocycle Q is R<7>, pyrrolidinyl substituted with R<7>, piperidinyl substituted with R<7> or homopiperidinyl substituted with R<7>; one of R<2a >and R<3a >is selected from halo, optionally mono- or polysubstituted Cl-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar<2>, N(R<4a>R<4>), N(R<4a>R<4>)sulfonyl, N(R<4a>R<4b>)carbonyl, C1-6alkyloxy, Ar<2>oxy, Ar<2>Cl-6alkyloxy, carboxyl, Cl-6alkyloxycarbonyl, or -C(=Z)Ar<2>; and the other one of R<2a >and R<3a> is hydrogen; in case R<2a >is different from hydrogen then R<2b >is hydrogen, C1-6alkyl or halogen and R<3b >is hydrogen; in case R<3a >is different from hydrogen then R<3b> is hydrogen, C1-6alkyl or halogen and R<2b >is hydrogen. It further concerns the preparation thereof and compositions comprising these compounds, as well as the use thereof as a medicine.