| 摘要 |
#CMT# #/CMT# Type 1 thrombospondin repeat peptides (I) are new. #CMT# : #/CMT# Peptides (I) comprising SEQ ID NO:10 are new, except for the peptide with SEQ ID NO:1. X2-Gly-Trp-Ser-Ser-X1-Ser-X3 (SEQ ID NO:10) Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser-Cys-Gly (SEQ ID NO:1) X1 : Cys or Abu; X2 : Trp-Ser, Trp-Abu or Leu-Nal2-Ser; X3 : Arg-Ser, Arg-Abu or Lys(iPr)-Ser. #CMT#ACTIVITY : #/CMT# Neuroprotective. #CMT#MECHANISM OF ACTION : #/CMT# Nerve cell growth stimulant. B104 neuroblastoma cells cultured for 3 days in a medium containing the peptide Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser (SEQ ID NO:2) had a maximum neurite length of 0.196 mm, comprared with 0.148 mm for control cultures. #CMT#USE : #/CMT# (I) are useful for regenerating cells of the nervous system and for preparing medicament for treating neurodegenerative diseases. #CMT#ADVANTAGE : #/CMT# (I) have better stability in aqueous solution than the peptide with SEQ ID NO:1. #CMT#SPECIFIC PEPTIDES : #/CMT# 5 Peptides are specifically claimed, e.g. Trp-Ser-Gly-Trp-Ser-Ser-Abu-Ser-Arg-Ser (SEQ ID NO:4). #CMT#EXAMPLE : #/CMT# A solution prepared by adding 1.1 ml water to 0.4 ml of an aqueous solution of Trp-Ser-Gly-Trp-Ser-Ser-Abu-Ser-Arg-Ser (1.5 mg/ml) was kept at 22[deg] C and 50% relative humidity. The residual peptide content after 7 days was 99.6%, compared with 22.4% for Trp-Ser-Gly-Trp-Ser-Ser-Cys-Ser-Arg-Ser-Cys-Gly. |
