LAMININ BINDING SITE

摘要

The present invention in one aspect relates to a ligand binding site for binding a laminin, particularly those laminins comprising an a5 chain. The invention also encompasses binding sites on Lutheran glycoprotein ("Lu gp") for binding laminin ("LM") isoforms containing an a5 chain, mutant Lu gp molecules impaired at this binding site, antagonists and enhancers of the site, methods for identifying antagonists and enhancers, and uses of these molecules.