| 摘要 |
<p>Described herein is a stable ocular device that immobilizes and delivers a bioactive agent to the eye over sustained periods of time. For example, the ocular device comprises a polymeric matrix which is produced by the polymerization of a composition comprising a silicone-containing prepolymer and comprises: (i) a bioactive agent which is immobilized within the polymeric matrix by an electrostatic interaction, a hydrophobic/hydrophobic interaction, or any combination thereof, wherein the bioactive agent comprises a drug which comprises rebamipide, olaptidine, cromoglycolate, cromolyn sodium, cyclosporine, nedocromil, levocabastine, lodoxamide, ketotifen, pimecrolimus, hyaluronan, or the pharmaceutically acceptable salt or ester thereof; and (ii) a carrier agent which is polyacrylic acid or polymethacrylic acid, wherein the carrier agent and bioactive agent are incorporated within the polymer matrix throughout the entire polymer matrix.</p> |
