| 摘要 |
The invention relates to a method for modifying non-specific inhibitors of 11 beta hydroxysteroid dehydrogenase (11 beta HSD) with a basic pentacyclic framework of the oleanan and ursan type, in order to be able to synthesize chemical compounds which inhibit 11 beta hydroxysteroid dehydrogenase and which, preferably, inhibit the substantially specific iso form of 11 beta hydroxysteroid dehydrogenase type 1, and which thus have substantially no inhibiting effect on the iso form of 11 beta hydroxysteroid dehydrogenase type 2 (11 beta HSD2). The invention further relates to novel chemical compounds with basic nor-oleanan or non-ursan frameworks. These inhibitors act as substantially specific inhibitors of 11 beta HSD1 and are thus suitable for the treatment and prevention of diabetes, metabolic syndrome, adiposis, corpulence, overweight, hyperlipoproteinemia, hypoglycemia, hyperinsulinemia, arteriosclerosis, dementia, depressions, osteoporosis, glaucoma, or virus diseases. |
