Substituted arylamino -1,2,3,4-tetrahydro naphthalenes and -2,3-dihydro-1H-indenes as potassium channel modulators

摘要

This invention provides compounds of formula I where Ar₁ is a 5- to 10-member mono- or bicyclic aromatic group, optionally substituted; where the -NR₃R₄ group is situated ortho to the NHC(-X) group; n=1 or 2; X-O or S; Y is O or S; and q=1 or 0. The invention also provides pharmaceutical compositions comprising compounds of formula I and/or salts, esters, and prodrugs thereof. These compounds modulate the activation and inactivation of potassium channels. The compounds are useful for the treatment and prevention of diseases and disorders-such as seizure disorders-which are affected by modulation of potassium ion channels.