LIPOSOME ENCAPSULATING AMMINE-PLATINUM COMPLEX AT HIGH CONCENTRATION, AND METHOD FOR PRODUCTION OF THE LIPOSOME

摘要

Disclosed is a method for producing a liposome encapsulating an ammine-platinum complex. The method comprises the steps of: A) providing a water-soluble ammine-platinum complex, a platinum complex raw material or a combination thereof; B) providing a liposome, a liposome raw material or a combination thereof; and C) preparing a mixture of the water-soluble ammine-platinum complex, the platinum complex raw material or the combination thereof and the liposome, the liposome raw material or the combination thereof and subjecting the mixture under the conditions where a liposome can be formed and maintained, wherein a salt formed by the platinum complex is in a water-soluble form at the time point where the liposome exists.