Methods for Treating Hiv by Inhibiting Cd4 Down-Modulation

摘要

The present invention provides methods for inhibiting the ability of HIV genes products to bind to the cytoplasmic domain of a CD4 receptor. This domain is necessary to the ability of the HIV Nef and Vpu gene products to connect the CD4 receptor to cellular degradation pathways. The present invention provides a method for introducing a modified CD4 receptor into a cell, and inhibitors thereof, to treat HIV infection and CD4 receptor down-modulation. The present invention is also directed to a method for screening compounds for the ability to inhibit CD4 down-modulation.