摘要 |
The present teachings provide carboxylic amide compounds that can modulate the activity of ion channels in a mammal. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels. |
申请人 |
WYETH;GALULLO, VINCENT;ZELLE, ROBERT;MAZDIYASNI, HORMOZ;BAKER, CHRISTOPHER, TODD;WILL, PAUL;GUO, JINSONG;FENSOME, ANDREW;SOENEN, DANIELLE;KERN, JEFFREY, CURTIS;MOORE, WILLIAM, JAY;MELENSKI, EDWARD, GEORGE;KAPLAN, JUSTIN;SABATUCCI, JOSEPH, PETER |
发明人 |
GALULLO, VINCENT;ZELLE, ROBERT;MAZDIYASNI, HORMOZ;BAKER, CHRISTOPHER, TODD;WILL, PAUL;GUO, JINSONG;FENSOME, ANDREW;SOENEN, DANIELLE;KERN, JEFFREY, CURTIS;MOORE, WILLIAM, JAY;MELENSKI, EDWARD, GEORGE;KAPLAN, JUSTIN;SABATUCCI, JOSEPH, PETER |