USE OF D-SERINE DERIVATIVES FOR THE TREATMENT OF ANXIETY DISORDERS

摘要

Compounds of Formula I are useful for the treatment of anxiety disorders such as generalized anxiety disorder (GAD), panic attack, post traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD) and social phobias. wherein: A is chosen from: aryl or heteroaryl, A being optionally substituted with up to 5 independently-selected groups R⁸; R¹ is chosen from: alkyl or haloalkyl; R² is chosen from: H, C(O)R⁶, C(O)OR⁶, SO2R⁶ or C(O)NR⁶R⁷; R³, R⁴ and R⁵ are independently chosen from: H or alkyl; R⁶and R⁷ are independently chosen from: H or alkyl; and R⁸ is chosen from: OH, CN, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, C(O)R⁶, C(O)OR⁶, SO2R⁶ or C(O)NR⁶R⁷.