发明名称 |
TRPV1+ SENSORY NEURONS CONTROL OF BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES |
摘要 |
<p>A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-ß-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.</p> |
申请公布号 |
WO2008070992(A1) |
申请公布日期 |
2008.06.19 |
申请号 |
WO2007CA02254 |
申请日期 |
2007.12.13 |
申请人 |
THE HOSPITAL FOR SICK CHILDREN;DOSCH, HANS-MICHAEL;TANG, LAN;CHAN, YIN;SALTER, MICHAEL |
发明人 |
DOSCH, HANS-MICHAEL;TANG, LAN;CHAN, YIN;SALTER, MICHAEL |
分类号 |
A61K38/08;A61K38/02;A61P3/10 |
主分类号 |
A61K38/08 |
代理机构 |
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地址 |
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