| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for generation of a xenogeneic-specific binding protein in non-human living hosts. <P>SOLUTION: The method comprises a process in which the embryonic stem cells and the yeast spheroplasts (wherein, spheroplasts comprising the yeast artificial chromosomes (YAC) comprising the xenogeneic DNA fragments and a marker for selection, and the xenogeneic DNA fragments are introduced in the embryonic stem cells by it) are bound in a condition for fusion, and selecting the embryonic stem cells having the xenogeneic DNA fragments by the marker. <P>COPYRIGHT: (C)2008,JPO&INPIT |
