METHODS FOR IMPROVING ANTIBODY PRODUCTION

摘要

The present invention encompasses manufacturing of antibody variants, suc h as variant of huC242, or fragments thereof, wherein the variants are manuf actured by substituting one or more amino acid residues in a parent antibody . Such substitution(s) is preferably done in a variable region framework seq uence of the parent antibody comprising a heavy and a light chain. As a cons equence of such substitution(s), variant antibodies or fragments thereof sho w enhanced antibody synthesis when introduced in a host cell as compared to the parent antibody.