1,3-Dihydro-Benzimidazol-2-Ylidene Amines as Inhibitors of Respiratory Syncytial Virus Replication

摘要

Novel 1,3-dihydro-benzimidazol-2-ylidene amine derivatives of formula the addition salts and stereochemically isomeric forms wherein each Alk is C_1-6alkanediyl; Q is hydrogen; C_1-6alkyl substituted with one or two Ar² radicals; CI_1-6alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; -CO-Ar²; or Q is a radical of formula wherein t is 1, 2 or 3; R⁴ is amino, mono- or di(C_1-6alkyl)amino; R¹ is Ar², -CO-Ar² or a monocyclic or bicyclic heterocycle which may optionally be substituted; R² is as R¹ and additionally can be hydrogen; where Q is other than hydrogen, R³ is hydrogen; and where Q is other than hydrogen, R³ is a radical: wherein R⁶ is hydrogen, C_1-6alkyl, substituted C_1-6alkyl; R⁷, R⁸, R⁹ are halo, cyano, C_1-6alkyl, substituted C_1-6alkyl, C_2-6alkenyl, cyanoC_2-6alkenyl, C_2-6alkynyl, cyanoC_{2 6}alkynyl, Ar¹, R^10a-0-, R^10a -S-, -N(R^5aR^5b), R^10a-O-C(-O)-, N(R^5aR^5b)-C(-O)-, R^10a-C(-O)-NR^5b1', R^10b-C(-O)-O-; and R⁸ and/or R⁹ may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.