摘要 |
Process for the preparation of (S)-(-)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide of Formula (I) by the steps of condensation of (S)-2-amino butanol of Formula (II) and 4-halobutryl chloride, where halo group can be chloro, bromo or iodo in solvents to form alpha-ethyl-2-oxo pyrrolidine ethanol of Formula (III); oxidation of (S)-alpha-ethyl-2-oxo pyrrolidine ethanol to yield (S)-alpha-ethyl-2-oxo pyrrolidine acetic acid having the formula (IV); esterification of (S)-alpha-ethyl-2-oxo pyrrolidine acetic acid (IV) with an alcohol to provide alkyl ester of Formula (V) wherein, R is 14 Carbon atom; ammonolysis of alkyl esters of formula (V) with ammonia to provide (S)-(-)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide of formula (1).
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