<p>The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.</p>
申请公布号
WO2008073195(A2)
申请公布日期
2008.06.19
申请号
WO2007US23359
申请日期
2007.11.06
申请人
DUKE UNIVERSITY;SPASOJEVIC, IVAN;COLVIN, MICHAEL, O.;BATINIC-HABERLE, INES;LUDEMAN, SUSAN, M.;GAMCSIK, MICHAEL, P.
发明人
SPASOJEVIC, IVAN;COLVIN, MICHAEL, O.;BATINIC-HABERLE, INES;LUDEMAN, SUSAN, M.;GAMCSIK, MICHAEL, P.