发明名称 |
MODIFICATION OF IONIC STRENGTH IN ANTIBODY-SOLUTIONS TO REDUCE OPALESCENCE/AGGREGATES |
摘要 |
Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification methods which monitor and/or reduce the salt concentrations at selected steps are also disclosed. |
申请公布号 |
WO2008045563(A3) |
申请公布日期 |
2008.06.19 |
申请号 |
WO2007US21904 |
申请日期 |
2007.10.12 |
申请人 |
WYETH;NICHOLS, PILARIN, ELIZABETH;LUISI, DONNA, LORRIANN |
发明人 |
NICHOLS, PILARIN, ELIZABETH;LUISI, DONNA, LORRIANN |
分类号 |
A61K39/395;A61K9/00;A61K47/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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