THIOPHENE DERIVATIVES AS PPAR AGONISTS I

摘要

The invention discloses compounds of formula (I); wherein: R is a carboxylic acid or a derivative thereof; R¹ is alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkylthio, halo or trihalomethyl; R² is aryl, heteroaryl, arylalkyl or heteroarylalkyl; R³ is H or F; and L is a linking group comprising a chain of from 2 to 8 atoms linking R and the carbonyl group (A); and pharmaceutically acceptable derivatives thereof, useful for treating disorders mediated by peroxisome-proliferator-activated receptor (PPAR) subtype d (PPARd). The compounds of the invention are therefore useful in the treatment of metabolic syndrome, obesity, type-II diabetes, dyslipidemia, wound healing, inflammation, neurodegenerative disorders and multiple sclerosis.