The description discloses that amiloride-like compounds inhibit enterovirus RNA replication by interaction with RNA dependent RNA polymerase (RdRP). The description discloses in silico and in vitro methods of screening for inhibitors of RdRP activity, amiloride-resistant enterovirus variants and amiloride-like compounds.
申请公布号
WO2008070924(A1)
申请公布日期
2008.06.19
申请号
WO2007AU01930
申请日期
2007.12.13
申请人
PICORAL PTY LTD;GAZINA, ELENA, V.;PETROU, STEVEN;HARRISON, DAVID, N.;ANDERSON, DAVID, A.
发明人
GAZINA, ELENA, V.;PETROU, STEVEN;HARRISON, DAVID, N.;ANDERSON, DAVID, A.