ADAMANTYLUREA COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS

摘要

Disclosed are urea compounds of formula I, stereoisomer, or pharmaceutical acceptable salts thereof, and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related diseases. wherein: X is a bond, C=O, or SO₂; Y is selected from the group consisting of alkyl, substituted alkyl, cycloalkyl. substituted cycloalkyl, heterocycloalkyl, substituted hetßrocycloalkyl. aryl, substituted aryl. heteroaryl, and substituted heteroaryl; and p is an integer equal to 1, 2, or 3.