METHODS, COMPOSITIONS AND KITS COMPRISING ATTENUATED ANTHRAX VACCINES AND METHODS OF DELIVERY

摘要

The present invention includes an attenuated Bacillus anthracis vaccine strain comprising a deletion in a nucleic acid encoding lethal factor and a deletion in a nucleic acid encoding PI-PLC or an attenuated Bacillus anthracis vaccine strain comprising a deletion in a nucleic acid encoding lethal factor and a deletion in edema factor. The present invention further comprises a method of immunizing a mammal against a Bacillus anthracis infection comprising administering the spores of an attenuated Bacillus anthracis vaccine strain intranasally.