NOVEL INHIBITORS OF BETA-LACTAMASE

摘要

This invention provides novel .beta.-lactamase inhibitors of the aryl-and heteroarylsulfonarnidomethylphosphonate monoester class having nitrogen-bas ed cations or quarternary ammomium groups. The compounds inhibit three class es of .beta.-lactamases and synergize the antibacterial effects of .beta.-la ctam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organ isms normally resistant to the .beta.-lactam antibiotics as a result of the presence of the .beta.-lactamases. Formula (I) or pharmaceutically acceptabl e salt thereof.