COMPUESTOS DERIVADOS DE 2,5-DIFENIL-1H-IMIDAZOL, MODULADORES DE LA ACTIVIDAD DE LA SENDA DE HEDGEHOG, UTIL PARA EL TRATAMIENTO DE CANCER DE PIEL SIN MELANOMA, MIELOMA, LINFOMA, SORIASIS, CANCER PANCREATICO, CANCER DE PROSTATA, MEDULOBLASTOMA, CARCINO

摘要

The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.