COMPUESTOS DERIVADOS DE MACROCICLOS, INHIBIDORES DE LA PROTEASA SERINA DE HEPATITIS C; PROCEDIMIENTO DE PREPARACION; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO DEL COMPUESTO PARA EL TRATAMIENTO DE LA HEPATITIS C.

摘要

Macrocyclic inhibitors of Hepatitis C protease are provided, the inhibitors including a boronic acid or ester group, a macrocyclic ring of about 13 to 25 atoms including at least two amide linkages, a proline-analogous group, and a connecting segment joining moieties on either side of the proline-analogous group. Methods of making the HCV protease-inhibitory compounds, methods of using the compounds, formulations of the compounds, and pharmaceutical combinations including the compounds, are provided.