NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS

摘要

2-aryl-4-quinolones are converted into phosphates by reacting with tetrab enzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subj ect to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Na+ form) to form disodium salts. The results of prel iminary screening revealed that these phosphates showed significant anti-can cer activity. A novel intermediate, 2-selenophene 4-quinolone and .LAMBDA./, .LAMBDA./-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also s ynthesized. These novel intermediates exhibited significant anticancer activ ities.