| 摘要 |
A composition for removal of biofilm in the ears is useful for the treatm ent of ear infections such as otitis media, particularly those infections ca used by Pseudomonas aeruginosa. In general, the composition comprises: (1) a quantity of at least one enzyme that catalyzes the hydrolysis of a bond tha t connects two monosaccharides in a polysaccharide or that connects a monosa ccharide with a protein molecule in a glycoprotein sufficient to break down biofilm in the ear; and (2) a pharmaceutically acceptable carrier suitable f or administration into the ear canal. The composition can further include in gredients such as a steroid, lysozyme, lactoferrin, or a peroxidase; if a pe roxidase is included, the composition can further include an oxidase to gene rate peroxide as well as a substrate for the oxidase. The composition can be used in methods for treatment of an ear infection based on the ability of t he composition to dissolve biofilm in the ear.
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