USE OF 1,2,3-SUBSTITUTED INDOLIZINE DERIVATIVES, INHIBITORS OF FGFS, FOR THE PREPARATION OF A MEDICAMENT INTENDED FOR THE TREATMENT OF DEGENERATIVE JOINT DISEASES

摘要

The present invention concerns the use of 1,2,3-substituted indolizine derivatives of formula (I), as defined in the description; (I) and in particular the 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoic acid, and their pharmaceutically acceptable salts and solvates for the preparation of a medicament intended for the treatment of degenerative joint diseases, such as osteoarthritis, spondyloses, cartilage loss following joint trauma or a relatively long period of joint immobilization following meniscus or patella injuries or ligament ruptures, and chronic diseases of the locomotory apparatus such as inflammatory, immunological or metabolism-associated acute and chronic arthritides, arthropathies, myalgias and disturbances of bone metabolism.