Process for producing carbapenem derivative having a 1-alkylpyrrolidine structure

摘要

A process for the preparation of carbapenem-type antibacterial agents involving the following reaction: wherein R¹ is a C₁-C₃ alkyl group, n is 0, 1 or 2, A is a C₁-C₃ alkylene group, L is a leaving group, R³ is a hydrogen atom, a C₁-C₃ alkyl group or an amino protecting group, and the hydroxyl or carboxyl groups are optionally independently protected. In such process, amine compound (1) or a salt thereof acts as a synthetic intermediate. Such process is a less expensive and highly safe synthetic route for carbapenem-type antibacterial agents suitable for large-scale synthesis.