Process For Producing Optically Active Beta-Hydroxy-Alpha-Aminocarboxylic Acid Derivative

摘要

There is provided a process for efficiently producing an anti form of an optically active beta-hydroxy-alpha-aminocarboxylic acid derivative that is useful as an intermediate for pharmaceuticals and agrochemicals. The process for producing optically active beta-hydroxy-alpha-aminocarboxylic acid derivative of formula (2) or (3) therein R¹ is substituted or unsubstituted C_1-20 alkyl group, or substituted or unsubstituted C_4-12 aromatic group, R² is substituted or unsubstituted C_1-20, alkyl group, or substituted or unsubstituted C_4-12 aromatic group, comprising subjecting an alpha-aminoacyl acetic acid ester compound of formula (1) wherein R¹ and R² have the same meaning as the above, to hydrogenation by catalytic asymmetric hydrogenation in the presence of an acid by using as a catalyst a rhodium complex containing as a ligand an optically active compound of formula (4), (4') or (5) characterized in that the hydrogenation is conducted in the presence of an acetic acid salt.