SUBSTITUTED THIENOPYRIDONE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY
摘要
Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side chroman group or left hand side tetrahydroquinoline group and a right hand side thienopyridone group. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
申请公布号
WO2008039639(A3)
申请公布日期
2008.06.12
申请号
WO2007US78124
申请日期
2007.09.11
申请人
REPLIDYNE, INC.;GUILES, JOSEPH;SUN, XICHENG;JANJIC, NEBOJSA;STRONG, SARAH
发明人
GUILES, JOSEPH;SUN, XICHENG;JANJIC, NEBOJSA;STRONG, SARAH