| 摘要 |
Disclosed are compositions and methods which provide an integrated approach to genotoxicity assessment procedures by employing a genetically engineered cell line to report on a number of key indicators of genotoxicity effects and mechanisms. Imaging and analysis of cells exposed to test agents allows automated analysis using high content cellular screening to identify cytostatic and/or cytotoxic activity, to quantify micronuclei formation, to discriminate aneugenic and clastogenic micronuclei and to detect DNA mutation and repair.
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