| 摘要 |
<p>The invention provides for a chimeric HIV-1 construct, EcoHIV, capable of replication in a rodent cell. The invention also provides a convenient and safe rodent model of HIV-1 infection and AIDS. A rodent model of HIV-1 infection is also provided which is useful for screening of candidate anti-viral drugs. Additionally, the invention provides for a method to test immunogenic compositions or pharmaceutical interventions effective in preventing infection, reducing viral load, or reducing disease symptoms in a subject.</p> |
| 申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;POTASH, MARY, JANE;VOLSKY, DAVID, J. |
发明人 |
POTASH, MARY, JANE;VOLSKY, DAVID, J. |
