CHITOSAN-COATED CALCIUM SULFATE BASED MEDICAMENT DELIVERY SYSTEM

摘要

A biodegradable medicament delivery system comprising a multi-layered calcium- sulfate based drug delivery vehicle. The vehicle comprises a calcium sulfate center or core with the medicament or medicaments, encased in one or more layers of chitosan. The chitosan may be cross-linked with a cross-linking agent. The vehicle may comprise any suitable shape, including, but not limited to, a sphere, bead or pellet. Medicaments include, but are not limited to, antibiotics, anesthetics, growth factors, and proteins. A physician can implant the coated vehicles into the desired site to create a beneficial, localized treatment that produces high local concentrations of medication while reducing the overall serum concentration throughout the body.