Bi- or Tetra-Guanidino-Biphenyl Compounds as Small Molecule Carriers

摘要

The invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein X₁, X₂ and X₃ are each independently where Y is an alkylene, alkenylene or alkynylene group, each of which may be optionally substituted with one or more substituents selected from alkyl, halo, CF₃, OH, alkoxy, NH₂, CN, NO₂ and COOH; W is absent or is O, S or NH; R₁, R₂, R₃ and R₄ are each independently selected from H, alkyl, aryl and a protecting group P₁; R₇, R₈ and R₉ are each independently selected from H, alkyl, halo, CF₃, OH, alkoxy, NH₂, CN, NO₂ and COOH; q and r are each independently 1, 2, 3 or 4; q' and r' are each independently 0, 1, 2 or 3, where q+q' and r+r' each equal 4; p is 1, 2, 3, 4 or 5, and p' is 0, 1, 2, 3 or 4, where p+p' is 5; n is 0, 1, 2, 3 . . . 6; L is (Z)_mNR₅R₆ where Z is a hydrocarbyl group and m is 0 or 1; where R₅ and R₆ are each independently H, CO(CH₂)_jQ₁ or C-S(NH)(CH₂)_kQ₂ where j and k are each independently 0, 1, 2, 3, 4 or 5, and Q₁ and Q₂ are each independently selected from COOH, a chromophore or R₅, R₆ and the nitrogen to which they are attached together form