发明名称 |
ADRENAL GRK2 ACTIVITY AS A THERAPEUTIC TARGET FOR HEART FAILURE |
摘要 |
The present invention relates to compositions and methods for the treatment of failing hearts. More specifically, the present invention provides for the inhibition of G-protein coupled receptor kinase 2 activity in the adrenal gland, which, for example, decreases catecholamine secretion and the sympathetic burden of the failing heart, thereby improving the cardiac adrenergic/inotropic reserve and overall contractile function. |
申请公布号 |
WO2008069890(A2) |
申请公布日期 |
2008.06.12 |
申请号 |
WO2007US23628 |
申请日期 |
2007.11.09 |
申请人 |
THOMAS JEFFERSON UNIVERSITY;LYMPEROPOULOS, ANASTASIOS;KOCH, WALTER, J. |
发明人 |
LYMPEROPOULOS, ANASTASIOS;KOCH, WALTER, J. |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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