Transcription factor for killer cell activation, differentiation and uses thereof

摘要

The present invention provides methods for altering activation and/or differentiation of Killer cells comprising altering the expression of a Homologue Of Blimp-1 In T-cells (Hobit) species in said Killer-cells. The invention further provides methods and means for increasing or decreasing expression of a Hobit species in Killer cells, and provides isolated and/or recombinant nucleic acid and uses of said isolated and/or recombinant nucleic acid.