发明名称 |
METHODS OF ALTERING AN IMMUNE RESPONSE INDUCED BY D-TYPE CPG OLIGODEOXYNUCLEOTIDES |
摘要 |
It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided. |
申请公布号 |
EP1929014(A1) |
申请公布日期 |
2008.06.11 |
申请号 |
EP20060813920 |
申请日期 |
2006.08.28 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES |
发明人 |
KLINMAN, DENNIS, M.;GURSEL, MAYDA;GURSEL, IHSAN |
分类号 |
A61K31/711;C12N15/11;C12N15/117 |
主分类号 |
A61K31/711 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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